1/17/2024 0 Comments Slice of life sims 4 december 2020This index of allostatic load was found to be a better predictor of mortality and decline in physical functioning than individual biomarkers alone, yet a number of limitations emerged due to the complexity and dynamic nature of this multisystem network. ![]() Additional biomarkers (glucose levels, lipid profiles, interleukin-6, heart rate variability) have subsequently been recognized as having a role in the allostatic load response and were then included in a cumulative index of allostatic load, commonly known as the “allostatic load battery”. Biological markers of diseases resulting from a condition of allostatic load were defined as tertiary mediators. The first four parameters have been considered as primary mediators of allostatic load because of their immediate correlation with adrenal function, whereas the remaining parameters were defined as secondary mediators. identified 10 biological parameters: cortisol, dehydroepiandrosterone (DHEA), epinephrine, norepinephrine, cholesterol, glycosylated hemoglobin, resting systolic and diastolic blood pressure, body mass index, and waist-hip ratio. Several studies have focused on identifying allostatic load through biological markers. An integrated approach that includes both biological markers and clinimetric criteria is recommended. Assessment of allostatic load provides support to the understanding of psychosocial determinants of health and lifestyle medicine. Conclusions: The findings indicate that allostatic load and overload are associated with poorer health outcomes. They encompassed general population studies, as well as clinical studies on consequences of allostatic load/overload on both physical and mental health across a variety of settings. Results: A total of 267 original investigations were included. We considered only studies in which allostatic load or overload were adequately described and assessed in either clinical or non-clinical adult populations. A manual search of the literature was also performed, and reference lists of the retrieved articles were examined. Methods: PubMed, PsycINFO, Web of Science, and the Cochrane Library were searched from inception to December 2019. Objective: To summarize the current knowledge on allostatic load and overload and its clinical implications based on a systematic review of the literature. Allostatic load is identified by the use of biomarkers and clinical criteria. ![]() When environmental challenges exceed the individual ability to cope, then allostatic overload ensues. It involves the interaction of different physiological systems at varying degrees of activity. Introduction: Allostatic load refers to the cumulative burden of chronic stress and life events.
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